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Nifedipine dilates the main coronary arteries and coronary arterioles both in normal and ischemic regions resulting in an increase in blood flow and hence in myocardial oxygen delivery.

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The addition of nifedipine to a stable quinidine regimen may reduce the quinidine concentration by 50%; an enhanced response to nifedipine may also occur.

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Elderly patients over 65 years old may have a stronger reaction to this medicine and need smaller doses.

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